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KMID : 0377619880530020081
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Korean Jungang Medical Journal
1988 Volume.53 No. 2 p.81 ~ p.87
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Clinical Therapeutic Effects of Ofloxacin in the Treatment of Chlamydia Trachomatis or Ureaplasma Urealyticum Urethritis
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金喆洙/Kim, Cheol Soo
崔勝康/李武相/이진무/Choi, Seoung Kang/Lee, Moo Sang/Lee, Jin Moo
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Abstract
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Ofloxacin(OFLX, Tarivid?) is a new derivative of pyridonecarboxylic acid and is known to have a potent antichlamydial and aniiureaplasmal effect.
In this study, the effects of OFLX on Chlamydial or Ureaplasmal urethritis were examined in 30 patients.
OFLX was administered orally 2 times a day at a daily dose of 400mg for 5-10 days and following results were obtained.
1. The total clinical effecacy in Chlamydial or Ureaplasmal urethritis (30 cases); Excellent result was obtained in 25 cases(83.3%), good in 3 cases(10.0%); and poor in 2 cases(6.7%), the overall clinical effecacy rate was 93.3%.
(1) Clinical result of Chlamydial and Ureaplasmal urethritis(22 cases: 73.3%): Excellent result was obtained in 19 cases(86.4%), good in 2 cases(9.1%), and poor in 1 cases (4.5%), the overall efficacy rate was 95.5%.
(2) Clinical result of Ureaplasmal urethritis(8 cases: 26.7%); Excellent result obtained in 8 cases(75.0%0), good in 1 case(12.5%), and poor in 1 case(12.5%), the overall efficacy rate was 87.5%.
2. As adverse reaction, mild G I trouble was observed in 3 cases and mild skin eruption in 1 case. No abnormality induced by OFLX was recognized in laboratory findings.
Thus ofloxacin can be regarded as a effective and safe drug for the treatment of urethritis caused by C. trachomatis or U. urealyticum.
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